Genomics

Dataset Information

0

Ena-DATASET-DAVELAB-01-09-2017-13:58:58:766-116 - samples

ABSTRACT: Exome sequencing data for 1001 DLBCL patients and RNA sequencing data for 775 DLBCL patients

PROVIDER: EGAD00001003600 | EGA |

REPOSITORIES: EGA

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Publications

Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.

Reddy Anupama A   Zhang Jenny J   Davis Nicholas S NS   Moffitt Andrea B AB   Love Cassandra L CL   Waldrop Alexander A   Leppa Sirpa S   Pasanen Annika A   Meriranta Leo L   Karjalainen-Lindsberg Marja-Liisa ML   Nørgaard Peter P   Pedersen Mette M   Gang Anne O AO   Høgdall Estrid E   Heavican Tayla B TB   Lone Waseem W   Iqbal Javeed J   Qin Qiu Q   Li Guojie G   Kim So Young SY   Healy Jane J   Richards Kristy L KL   Fedoriw Yuri Y   Bernal-Mizrachi Leon L   Koff Jean L JL   Staton Ashley D AD   Flowers Christopher R CR   Paltiel Ora O   Goldschmidt Neta N   Calaminici Maria M   Clear Andrew A   Gribben John J   Nguyen Evelyn E   Czader Magdalena B MB   Ondrejka Sarah L SL   Collie Angela A   Hsi Eric D ED   Tse Eric E   Au-Yeung Rex K H RKH   Kwong Yok-Lam YL   Srivastava Gopesh G   Choi William W L WWL   Evens Andrew M AM   Pilichowska Monika M   Sengar Manju M   Reddy Nishitha N   Li Shaoying S   Chadburn Amy A   Gordon Leo I LI   Jaffe Elaine S ES   Levy Shawn S   Rempel Rachel R   Tzeng Tiffany T   Happ Lanie E LE   Dave Tushar T   Rajagopalan Deepthi D   Datta Jyotishka J   Dunson David B DB   Dave Sandeep S SS  

Cell 20171001 2

Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We chara  ...[more]

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