Dataset Information

Ena-DATASET-JHU-SOM-01-09-2017-17:11:13:045-143 - samples

ABSTRACT: The dataset for Direct Detection of Early-Stage Cancers using Circulating Tumor DNA includes 602 bam files from next-generation sequencing on the Illumina HiSeq2500 or MiSeq. The samples analyzed include cancer cell lines as well as plasma and tissue specimens from healthy individuals and patients with cancer.

PROVIDER: EGAD00001003601 | EGA |

REPOSITORIES: EGA

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Publications

Direct detection of early-stage cancers using circulating tumor DNA.

Phallen Jillian J Sausen Mark M Adleff Vilmos V Leal Alessandro A Hruban Carolyn C White James J Anagnostou Valsamo V Fiksel Jacob J Cristiano Stephen S Papp Eniko E Speir Savannah S Reinert Thomas T Orntoft Mai-Britt Worm MW Woodward Brian D BD Murphy Derek D Parpart-Li Sonya S Riley David D Nesselbush Monica M Sengamalay Naomi N Georgiadis Andrew A Li Qing Kay QK Madsen Mogens Rørbæk MR Mortensen Frank Viborg FV Huiskens Joost J Punt Cornelis C van Grieken Nicole N Fijneman Remond R Meijer Gerrit G Husain Hatim H Scharpf Robert B RB Diaz Luis A LA Jones Siân S Angiuoli Sam S Ørntoft Torben T Nielsen Hans Jørgen HJ Andersen Claus Lindbjerg CL Velculescu Victor E VE

Science translational medicine 20170801 403

Early detection and intervention are likely to be the most effective means for reducing morbidity and mortality of human cancer. However, development of methods for noninvasive detection of early-stage tumors has remained a challenge. We have developed an approach called targeted error correction sequencing (TEC-Seq) that allows ultrasensitive direct evaluation of sequence changes in circulating cell-free DNA using massively parallel sequencing. We have used this approach to examine 58 cancer-re ...[more]

PMID: 28814544

Dataset Information

Ena-DATASET-JHU-SOM-01-09-2017-17:11:13:045-143 - samples

Publications

Direct detection of early-stage cancers using circulating tumor DNA.

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