Project description:Fastq transcriptomic sequencing files from Z138 MCL cell line with differential SOX11 expression. Samples include SOX11 wild-type (WT), SOX11 knockout (KO), and SOX11 re-expression (resc) in the KO background. The dataset includes 3 biological replicates per condition.
Project description:AU-15330 treatment RNA-seq dataset: Fastq transcriptomic sequencing files from Z138 mantle cell lymphoma (MCL) cell line treated with the SMARCA4 degrader AU-15530. Cells were treated for 8 or 24 hours with 0.5 μM AU-15530 or control (DMSO). The dataset includes 3 biological replicates per condition (AU-15530 8h, AU-15530 24h, DMSO 8h, DMSO 24h).
Project description:To investigate the molecular effects of telomere damage in skeletal muscle by Terf2 knockout, we performed bulk RNA sequencing on gastrocnemius-plantaris-soleus (GPS) and tibialis anterior (TA) muscles isolated from Terf2 knockout (KO) and control (Cre) mice. Total RNA was extracted from dissected muscles and used for library preparation followed by paired-end sequencing. Samples include both male and female 8 month old mice. The dataset comprises biological replicates from KO and Cre genotypes for each muscle type. FASTQ files correspond to quality-filtered and trimmed reads used for alignment.
Project description:This experiment contains a subset of data from the BLUEPRINT Epigenome project ( http://www.blueprint-epigenome.eu ), which aims at producing a reference haemopoetic epigenomes for the research community. 29 samples of primary cells or cultured primary cells of different haemopoeitc lineages from cord blood are included in this experiment. This ArrayExpress record contains only meta-data. Raw data files have been archived at the European Genome-Phenome Archive (EGA, www.ebi.ac.uk/ega) by the consortium, with restricted access to protect sample donors' identity. The relevant accessions of EGA data sets is EGAD00001001165. Details on how to apply for data access via the BLUEPRINT data access committee are on the EGA data set pages. The mapping of samples to these EGA accessions can be found in the 'Sample Data Relationship Format' file of this ArrayExpress record. Information on individual samples and sequencing libraries can also be found on the BLUEPRINT data coordination centre (DCC) website: http://dcc.blueprint-epigenome.eu
Project description:This dataset contains bulk RNA sequencing data from paired aganglionic and ganglionic colonic tissue specimens obtained from three pediatric patients diagnosed with Hirschsprung disease (HSCR, OMIM 142623). RNA was extracted and sequenced to investigate transcriptomic alterations and signaling pathway dysregulation associated with HSCR pathogenesis. Raw paired-end FASTQ files generated by Illumina NovaSeq 6000 sequencing are provided for each sample, enabling downstream analyses of differential gene expression between diseased and unaffected intestinal segments.
2025-08-14 | GSE305450 | GEO
Project description:Metagenomics sequencing raw fastq files
Project description:The expression profile and sequence variants of 476 early stage urothelial carcinoma were studied using whole transcriptome sequencing. RNA-Seq libraries were prepared by Ribo-Zero treatment of total-RNA (to reduce the rRNA content) followed by library preparation using ScriptSeq. RNA-Seq libraries were paired-end sequenced (2x 101 bp) on Illumina HiSeq 2000 and the resulting fastq files were processed using tools from the Genome Analysis Toolkit (GATK and from the Tuxedo suite. Access to the sequence data (bam and vcf files), containing person identifying information, needs signature on a controlled access form, and can be accessed at The European Genome-phenome Archive (EGA) using the study ID EGAS00001001236 following request. An expression matrix of FPKM values are available without restriction at ArrayExpress.
