Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ena-DATASET-INSTITUTE OF CANCER RESEARCH-10-05-2018-15:21:10:264-271 - samples

ABSTRACT: The failure to develop effective therapies for paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. Analysis of 142 sequenced cases revealed multiple tumour subclones, spatially and temporally co-existing in a stable manner as observed by multiple sampling strategies. This dataset provides multi region sequencing of high grade gliomas and diffuse intrinsic pontine gliomas from 15 patients. DNA was extracted from FFPE sections in 2-13 regions of each tumour and sequenced with Agilent SureSelect whole exome sequencing. Germline DNA was also sequenced in 14 cases. Data was aligned to hg19 with bwa and is provided as 79 separate BAM files.

PROVIDER: EGAD00001004114 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Similar Datasets

Illumina Infinium HumanMethylation450 BeadChip profiling of paediatric high grade gliomas and diffuse intrinsic pontine gliomas

Project description:We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas and diffuse intrinsic pontine gliomas. The 450K methylation array is being used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of origin the time and place in which tumours arise. Methylation arrays provide data for an integrated molecular diagnosis of brain tumours and define specific molecular subgroups and subtypes of high grade gliomas carrying distinct driver mutations and patterns of somatic alterations. These data form part of an integrated meta-analysis of high grade gliomas in children combining DNA copy number, methylation and high throughput sequencing datasets.

2017-09-28 | E-MTAB-5528 | biostudies-arrayexpress

Wnt5a and its downstream transcription factor Stat3 are therapeutic targets for diffuse intrinsic pontine gliomas

Project description:Understand how Wnt5a depletion affects the growth of diffuse intrinsic pontine gliomas

2019-04-29 | GSE130407 | GEO

Homo sapiens

Project description:Genome-wide Analyses of Diffuse Intrinsic Pontine Gliomas

| PRJNA136251 | ENA

Circulating microRNA profiling in diffuse intrinsic pontine gliomas

Project description:Circulating microRNA profiling in diffuse intrinsic pontine gliomas

| PRJNA672708 | ENA

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Project description:This phase I trial studies the side effects and best dose of pembrolizumab and to see how well it works in treating younger patients with high-grade gliomas (brain tumors that are generally expected to be fast growing and aggressive), diffuse intrinsic pontine gliomas (brain stem tumors), brain tumors with a high number of genetic mutations, ependymoma or medulloblastoma that have come back (recurrent), progressed, or have not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may induce changes in the body’s immune system, and may interfere with the ability of tumor cells to grow and spread.

| 2183538 | ecrin-mdr-crc

SUV39H1 inhibition by Chaetocin targets stemness and oncogenic networks and synergizes with ONC201 against Diffuse intrinsic pontine gliomas [RNA-seq]

Project description:To investigate Chaetocin impact on Diffuse intrinsic pontine gliomas treatment We then performed gene expression profiling analysis using data obtained from RNA-seq of Chaetocin treatment and SUV39H1 knockdown in SU-DIPG36 cells

2025-02-08 | GSE225027 | GEO

ena-DATASET-INSTITUTE OF CANCER RESEARCH-17-12-2013-15:22:20:271-113 - samples

Project description:Whole exome sequencing of 6 tumour and normal pairs of diffuse intrinsic pontine glioma (DIPG)

| EGAD00001000706 | EGA

ena-DATASET-INSTITUTE OF CANCER RESEARCH-12-10-2021-12:28:50:240-178 - samples

Project description:RNA sequencing of Diffuse intrinsic pontine gliomas, primary patient derived DIPG cell cultures and isogenic trametinib resistant clones

| EGAD00001008212 | EGA

Utilizing Omomyc to Target MYCN-Amplified Diffuse Intrinsic Pontine Gliomas

Project description:Utilizing Omomyc to Target MYCN-Amplified Diffuse Intrinsic Pontine Gliomas

| PRJNA833664 | ENA

Targeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas

Project description:Targeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas

| PRJNA954672 | ENA