Genomics

Dataset Information

0

Ena-DATASET-UQDI-06-07-2018-03:19:47:723-1903 - samples


ABSTRACT: This dataset contains raw sequencing reads for matched MGUS/SMM to MM patient samples, including normal germline controls. FASTQ files were generated on Illumina NextSeq 500 and HiSeq 4000 machines following exome capture using the Agilent Clinical Research Exome kit. DNA was extracted from CD138+CD38++ cells (representing MGUS/SMM/MM cells) and CD138-CD38- (representing normal cells) isolated from bone marrow. 10 patients are included with 3 samples each representing normal, MGUS/SMM, MM stages.

PROVIDER: EGAD00001004190 | EGA |

REPOSITORIES: EGA

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Publications

Cutting edge genomics reveal new insights into tumour development, disease progression and therapeutic impacts in multiple myeloma.

Dutta Ankit K AK   Hewett Duncan R DR   Fink J Lynn JL   Grady John P JP   Zannettino Andrew C W ACW  

British journal of haematology 20170503 2


Multiple Myeloma (MM) is a haematological malignancy characterised by the clonal expansion of plasma cells (PCs) within the bone marrow. Despite advances in therapy, MM remains a largely incurable disease with a median survival of 6 years. In almost all cases, the development of MM is preceded by the benign PC condition Monoclonal Gammopathy of Undetermined Significance (MGUS). Recent studies show that the transformation of MGUS to MM is associated with complex genetic changes. Understanding how  ...[more]

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