Genomics,Multiomics

Dataset Information

0

1ac2d51a-68f2-4806-b480-6d650780e362 - samples


ABSTRACT: RNA-seq of 24 M-CSF differentiated human peripheral monocyte-derived macrophages (MDMs) activated with short exposure (3hours) to LPS, or long exposure (24 hours) to LPS, LPS with IFNγ, IFNγ, IL-4, IL-10, and dexamethasone.

PROVIDER: EGAD00001004584 | EGA |

REPOSITORIES: EGA

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Publications

Meta-Analysis of <i>in vitro</i>-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages <i>in vivo</i>.

Chen Hung-Jen HJ   Li Yim Andrew Y F AYF   Griffith Guillermo R GR   de Jonge Wouter J WJ   Mannens Marcel M A M MMAM   Ferrero Enrico E   Henneman Peter P   de Winther Menno P J MPJ  

Frontiers in immunology 20191211


Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While <i>in vitro</i> macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used <i>in vitro</i> macrophage models to perform a meta-analysis. Specifically, we obtained gene expression data from unstimulated macrophages (M0) and macrophages stimulated with lipopolysaccharid  ...[more]

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