Genomics

Dataset Information

0

Ba3dbe29-0fd7-4ee5-99b8-d69d3c381e6e - samples

ABSTRACT: The BAM files for WES and RNA seq used in the article "Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases." on cancer Discovery 2019. PMID: 30787016 PMCID: PMC6497554. Authors : Grant M Fischer, ..., Michael A Davies.

PROVIDER: EGAD00001005046 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.

Fischer Grant M GM   Jalali Ali A   Kircher David A DA   Lee Won-Chul WC   McQuade Jennifer L JL   Haydu Lauren E LE   Joon Aron Y AY   Reuben Alexandre A   de Macedo Mariana P MP   Carapeto Fernando C L FCL   Yang Chendong C   Srivastava Anuj A   Ambati Chandrashekar R CR   Sreekumar Arun A   Hudgens Courtney W CW   Knighton Barbara B   Deng Wanleng W   Ferguson Sherise D SD   Tawbi Hussein A HA   Glitza Isabella C IC   Gershenwald Jeffrey E JE   Vashisht Gopal Y N YN   Hwu Patrick P   Huse Jason T JT   Wargo Jennifer A JA   Futreal P Andrew PA   Putluri Nagireddy N   Lazar Alexander J AJ   DeBerardinis Ralph J RJ   Marszalek Joseph R JR   Zhang Jianjun J   Holmen Sheri L SL   Tetzlaff Michael T MT   Davies Michael A MA  

Cancer discovery 20190220 5

There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also underwent whole-exome sequencing, T-cell receptor sequencing, and IHC. MBMs demonstrated heterogeneity of immune infiltrates that correlated with prior radiation and post-craniotomy survival. Comparison with patient-matched extracranial metastases ident  ...[more]

Similar Datasets

Genomics Region-wide subsets of AR, FOXA1 and H3K27ac ChIP-Seq within three primary prostate adenocarcinoma, three metastatic castratation-resistant and prostate cell-lines.
2019-10-01 | GSE138168 | GEO
Genomics MicroRNA expression profiling in the adult offspring of rats with periodontal disease
2024-12-28 | GSE281235 | GEO
Transcriptomics Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes
2016-11-09 | GSE86473 | GEO
Genomics ChEC-Seq: a robust method to identify protein-DNA interactions genome-wide
2020-07-01 | GSE133645 | GEO
Proteomics The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5_2025
2025-11-04 | MSV000099757 | MassIVE
Proteomics CNB Lipid Rafts reAnalysis. - This dataset represents an example for a textbook: Genomics and Proteomics for Clinical Discovery and Development
2014-07-14 | PXD000744 | Pride
Genomics Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients
2011-06-06 | GSE27560 | GEO
Transcriptomics CAGE sequences from three developmental states in the microcrustacean Daphnia pulex.
2016-09-12 | GSE80141 | GEO
Genomics SNP arrays to detect copy number changes in t(1;19) E2A-PBX1 positive leukemias
2013-11-23 | GSE52654 | GEO
Transcriptomics Carbon sources tune antibiotic susceptibility in Pseudomonas aeruginosa via TCA cycle control
2016-12-20 | GSE90620 | GEO