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3a29872b-a736-415c-b42b-d2ee95d79c54 - samples

ABSTRACT: WGS with linked reads of pediatric glioblastoma. For each patient, blood and tumor tissue were sequenced. For two patients, we also provide sequencing data for the blood of their parents.

OTHER RELATED OMICS DATASETS IN: GSE117599

PROVIDER: EGAD00001005212 | EGA |

REPOSITORIES: EGA

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Publications

Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma.

Hoffman Mary M Gillmor Aaron H AH Kunz Daniel J DJ Johnston Michael J MJ Nikolic Ana A Narta Kiran K Zarrei Mehdi M King Jennifer J Ellestad Katrina K Dang Ngoc Ha NH Cavalli Florence M G FMG Kushida Michelle M MM Coutinho Fiona J FJ Zhu Yuankun Y Luu Betty B Ma Yussanne Y Mungall Andrew J AJ Moore Richard R Marra Marco A MA Taylor Michael D MD Pugh Trevor J TJ Dirks Peter B PB Strother Douglas D Lafay-Cousin Lucie L Resnick Adam C AC Scherer Stephen S Senger Donna L DL Simons Benjamin D BD Chan Jennifer A JA Morrissy A Sorana AS Gallo Marco M

Cancer research 20190315 9

Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were collections of genetically diverse subclones. Clonal composition rapidly evolved at recurrence, with less than 8% of nonsynonymous single-nucleotide variants being shared in diagnostic-recurrent ...[more]

PMID: 30877103

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