Dataset Information
Ena-DATASET-UMCU-04-11-2019-12:52:17:220-46 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001005476 | EGA |
REPOSITORIES: EGA
Publications
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
Nature medicine 20190422 5
Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of OC are limited and hard to establish. We present a protocol that enables efficient derivation and long-term expansion of OC organoids. Utilizing this protocol, we have established 56 organoid lines from 32 patients, representing all main subtypes of OC. OC organoids recapitulate histological and genomic features of the per ...[more]
