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Ena-DATASET-DKFZ-29-05-2020-15:56:12:496-205 - samples

ABSTRACT: ALI culture bronchial cells and alveolar lung surgical resection scRNA-Seq

PROVIDER: EGAD00001006185 | EGA |

REPOSITORIES: EGA

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SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.

Lukassen Soeren S Chua Robert Lorenz RL Trefzer Timo T Kahn Nicolas C NC Schneider Marc A MA Muley Thomas T Winter Hauke H Meister Michael M Veith Carmen C Boots Agnes W AW Hennig Bianca P BP Kreuter Michael M Conrad Christian C Eils Roland R

The EMBO journal 20200414 10

The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and replication. SARS-CoV-2 was reported to enter cells via binding to ACE2, followed by its priming by TMPRSS2. Here, we investigate ACE2 and TMPRSS2 expression levels and their distribution across cell types in lung tissue (twelve donors, 39,778 cells) and in cells de ...[more]

PMID: 32246845

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