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01597d9d-b85e-43c5-b035-cb21abfeb9e1 - samples

ABSTRACT: Whole exome sequencing of neuroendocrine cervical cancer

PROVIDER: EGAD00001006391 | EGA |

REPOSITORIES: EGA

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Comparative genomics of high grade neuroendocrine carcinoma of the cervix.

Hillman R Tyler RT Cardnell Robert R Fujimoto Junya J Lee Won-Chul WC Zhang Jianjun J Byers Lauren A LA Ramalingam Preetha P Leitao Mario M Swisher Elizabeth E Futreal P Andrew PA Frumovitz Michael M

PloS one 20200616 6

In order to improve treatment selection for high grade neuroendocrine carcinomas of the cervix (NECC), we performed a comparative genomic analysis between this rare tumor type and other cervical cancer types, as well as extra-cervical neuroendocrine small cell carcinomas of the lung and bladder. We performed whole exome sequencing on fresh-frozen tissue from 15 NECCs and matched normal tissue. We then identified mutations and copy number variants using standard analysis pipelines. Published muta ...[more]

PMID: 32544169

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