Dataset Information
Ena-DATASET-ErasmusMC-30-07-2021-13:58:26:615-766 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001007944 | EGA |
REPOSITORIES: EGA
Publications
EGFR mutations are associated with response to depatux-m in combination with temozolomide and result in a receptor that is hypersensitive to ligand.
Neuro-oncology advances 20191209 1
<h4>Background</h4>The randomized phase II INTELLANCE-2/EORTC_1410 trial on EGFR-amplified recurrent glioblastomas showed a trend towards improved overall survival when patients were treated with depatux-m plus temozolomide compared with the control arm of alkylating chemotherapy only. We here performed translational research on material derived from this clinical trial to identify patients that benefit from this treatment.<h4>Methods</h4>Targeted DNA-sequencing and whole transcriptome analysis ...[more]
