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5c638551-978c-4e80-b87e-d669d6b7069e - samples

ABSTRACT: Full information about the T cell receptor (CR) variable regions found in the sequences of the vdj region. Columns: barcode is_cell contig_id high_confidence length chain v_gene d_gene j_gene c_gene full_length productive cdr3 cdr3_nt reads umis raw_clonotype_id raw_consensus_id

PROVIDER: EGAD00001008109 | EGA |

REPOSITORIES: EGA

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SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.

Agerer Benedikt B Koblischke Maximilian M Gudipati Venugopal V Montaño-Gutierrez Luis Fernando LF Smyth Mark M Popa Alexandra A Genger Jakob-Wendelin JW Endler Lukas L Florian David M DM Mühlgrabner Vanessa V Graninger Marianne M Aberle Stephan W SW Husa Anna-Maria AM Shaw Lisa Ellen LE Lercher Alexander A Gattinger Pia P Torralba-Gombau Ricard R Trapin Doris D Penz Thomas T Barreca Daniele D Fae Ingrid I Wenda Sabine S Traugott Marianna M Walder Gernot G Pickl Winfried F WF Thiel Volker V Allerberger Franz F Stockinger Hannes H Puchhammer-Stöckl Elisabeth E Weninger Wolfgang W Fischer Gottfried G Hoepler Wolfgang W Pawelka Erich E Zoufaly Alexander A Valenta Rudolf R Bock Christoph C Paster Wolfgang W Geyeregger René R Farlik Matthias M Halbritter Florian F Huppa Johannes B JB Aberle Judith H JH Bergthaler Andreas A

Science immunology 20210301 57

CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation, IFN-γ production and cytotoxic activity of CD8+ T ...[more]

PMID: 33664060

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