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Ena-DATASET-VUMC-CCA-05-12-2021-12:21:28:910-387 - samples

ABSTRACT: small RNA next generation sequencing in head and neck cancer

PROVIDER: EGAD00001008402 | EGA |

REPOSITORIES: EGA

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Expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer.

Poel Dennis D Rustenburg François F Sie Daoud D van Essen Hendrik F HF Eijk Paul P PP Bloemena Elisabeth E Elhorst Benites Teresita T van den Berg Madeleine C MC Vergeer Marije R MR Leemans René C RC Buffart Tineke E TE Ylstra Bauke B Brakenhoff Ruud H RH Verheul Henk M HM Voortman Jens J

Oral oncology 20200622

<h4>Objectives</h4>The majority of patients with locally advanced larynx or hypopharynx squamous cell carcinoma are treated with organ-preserving chemoradiotherapy (CRT). Clinical outcome following CRT varies greatly. We hypothesized that tumor microRNA (miRNA) expression is predictive for outcome following CRT.<h4>Methods</h4>Next-generation sequencing (NGS) miRNA profiling was performed on 37 formalin-fixed paraffin-embedded (FFPE) tumor samples. Patients with a recurrence-free survival (RFS) ...[more]

PMID: 32585557

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