Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS). Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).

| 2533916 | ecrin-mdr-crc

Seeking insights into early onset colorectal cancer through analysis of normal colon organoids of Familial Adenomatous Polyposis patients

Project description:Here, we generated bulk RNA-seq data on colon organoids derived from both healthy and familial adenomatous polyposis patients. We related findings observed within this dataset to differential expression findings from a publicly available colorectal cancer cohort.

2022-10-13 | GSE207398 | GEO

Bulk RNA sequencing of ovarian tumor samples from high-grade serous ovarian cancer patients [RNA-Seq]

Project description:High-grade serous ovarian cancer (HGSOC) is thought to originate from the fallopian tube (FT), highlighting the importance of studying molecular features across tumor samples. This dataset contains bulk RNA sequencing data from tumor samples of HGSOC patients. The data can be used for driver mutations and copy number alterations (CNAs) profiling and analysis of gene expression patterns, including regions relevant to HLA typing. This submission contains bulk RNA sequencing data associated with this study.

2026-04-07 | GSE301179 | GEO

Bulk RNA sequencing of silk gland samples isolated from adult female L. sclopetarius spiders

Project description:This dataset comprises bulk RNA sequencing of 12 silk gland samples isolated from adult female L. sclopetarius spiders. The samples include whole major ampullate glands (5 replicates), flagelliform glands (3), (aciniform + pyriform) glands (4).

2024-05-15 | E-MTAB-14073 | biostudies-arrayexpress

GNPS - Polar metabolomics of plasma samples in Colorectal Cancer Patients

Project description:large-scale polar metabolomics analysis for plasma sample from colorectal cancer patients

| MSV000092836 | GNPS

Single-cell RNA-sequencing of colorectal cancer PDOX tumors treated with vehicle or the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan

Project description:Patient-derived colorectal cancer organoids were injected into mice to grow into subcutaneous tumors. Starting at 100 mm3, tumors were treated with Trodelvy (Sacituzumab Govitecan (SG)) or vehicle twice per week for 28 days before samples were harvested and subjected to single-cell RNA-sequencing of the tumor cells.

2026-04-29 | E-MTAB-16433 | biostudies-arrayexpress

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