Project description:Interventions: Gold Standard:;Index test:
Primary outcome(s): concentration of cell-free DNA in plasma;integrity of cell-free DNA in plasma
Study Design: Diagnostic test: case-control
| 2662278 | ecrin-mdr-crc
Project description:Cell free plasma DNA sequenced for T-cell Lymphoma patients
| PRJNA822697 | ENA
Project description:Detection of Pneumonia Pathogens from Plasma Cell-Free DNA
| PRJNA525157 | ENA
Project description:Detection of brain-derived cell free DNA in plasma
Project description:Cell-free DNA fragmentation is a nonrandom process. We showed that cell-free DNA fragments with ends at certain genomic coordinates had higher likelihoods of being derived from hepatocellular carcinoma. Other coordinates were associated with cell-free DNA molecules originating from the liver. Quantitative assessment of cell-free DNA molecules bearing these respective groups of end signatures correlated with the amounts of tumor-derived or liver-derived DNA in plasma. There were millions of tumor-associated plasma DNA end coordinates across the genome. Due to their high prevalence, they were more readily detectable than somatic mutations as a cancer signature in plasma. Hence, detection of tumor-associated plasma DNA ends may offer a cost-effective means of capturing evidence for the presence of cancer through liquid biopsy assessment.
| EGAS00001003160 | EGA
Project description:Bisulfite sequencing cell free DNA mouse