Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

4a623a1f-fde2-45ee-82dd-11cd46089eba - samples

ABSTRACT: WGS Cram files from the Childhood Cerebral Palsy Integrated Neuroscience Discovery Network "CP-NET" - Clinical Database Platforms - Phase 3 project.

PROVIDER: EGAD00001010014 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Similar Datasets

Screening of Cerebral Palsy Biomarkers and Cross-Species Conservative Target Analysis between Human and Mouse Based on Whole Transcriptome Array Chip Sequencing_circRNA-seq

Project description:Cerebral Palsy (CP) is a group of neurodevelopmental disorders characterized by persistent motor and posture impairments. Its molecular mechanisms remain poorly understood, and there is a lack of reliable blood-based biomarkers. This study employed circRNA-seq technology to analyze the expression profiles of circRNAs in peripheral blood from 3 children with cerebral palsy and 3 healthy controls.

2026-06-08 | GSE334222 | GEO

Clinically Relevant Copy Number Variations Detected in Cerebral Palsy

Project description:Cerebral palsy (CP) represents a group of non-progressive clinically heterogeneous disorders that are characterized by motor impairment and early age-of-onset, frequently accompanied by co-morbidities. The cause of CP has historically been attributed to environmental stressors resulting in brain damage. While genetic risk factors are also implicated, guidelines for diagnostic assessment of CP do not recommend for routine genetic testing. Given numerous reports of etiologic copy number variations (CNVs) in other neurodevelopmental disorders, we used microarrays to genotype a population-based prospective cohort of children with CP and their parents. Here we identify de novo CNVs in 8/115 (7.0%) CP patients (~1% rate in controls). In four children, large chromosomal abnormalities deemed pathogenic were found, and they were significantly more likely to have severe neuro-motor impairments than those CP subjects without such alterations. Overall the CNV data would have impacted our diagnosis or classification of CP in 11/115 (9.6%) families. Dr. Maryam Oskoui* , Mr. Matthew Gazzellone* , Ms. Bhooma Thiruvahindrapuram , Dr. Mehdi Zarrei , Dr. John Andersen , Dr. John Wei , Dr. Zhouzhi Wang , Dr. Richard Wintle , Dr. Christian Marshall , Dr. Ronald Cohn , Dr. Rosanna Weksberg , Dr. James Stavropoulos , Dr. Darcy Fehlings , Dr. Michael Shevell, Dr. Stephen Scherer. Clinically Relevant Copy Number Variations Detected in Cerebral Palsy. Nature Communications, 2015. Following our rigorous quality control procedure, we successfully genotyped 147 proband samples from individuals with cerebral palsy (81 males and 66 females) and 282 samples obtained from parents (134 males and 148 females). This facilitated the identification of de novo and rare inherited copy number variations of clinical interest.

2015-07-28 | E-GEOD-70374 | biostudies-arrayexpress

Whole-transcriptome RNA sequencing-based biomarker screening and human-mouse cross-species conserved target analysis for cerebral palsy_Rattus norvegicus_circRNAseq

2026-05-08 | GSE330456 | GEO

Whole-transcriptome RNA sequencing-based biomarker screening and human-mouse cross-species conserved target analysis for cerebral palsy_Rattus norvegicus_miRNAseq

2026-05-08 | GSE330445 | GEO

Whole-transcriptome RNA sequencing-based biomarker screening and human-mouse cross-species conserved target analysis for cerebral palsy_Homo sapiens_miRNAseq

2026-05-08 | GSE330444 | GEO

Genome-wide analysis of circular RNAs in cerebral palsy

Project description:Cerebral palsy (CP) is a spectrum of non-progressive motor disorders caused by brain injury during fetal or postnatal periods. Current diagnosis of CP mainly relies on neuroimaging and motor assessment, and we aimed to explore novel biomarkers for CP diagnosis in the present study. Blood plasma from five CP children and their healthy twin brothers/sisters was analyzed by gene microarray to screen out differential expressed circular RNAs (circRNAs).

2021-09-01 | GSE183021 | GEO

Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise [EV]

Project description:In this study, the properties of circulating EVs were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise. We performed smallRNA-seq anf focused on the microRNA cargo of EVs

2022-12-10 | GSE218103 | GEO

Clinically Relevant Copy Number Variations Detected in Cerebral Palsy

2015-07-28 | GSE70374 | GEO

A Dysregulated Proinflammatory Status in Preterm School-aged Children with PVL-induced Spastic Cerebral Palsy

Project description:Injury occurring during critical periods of development may have long-term effects on inflammatory responses. Periventricular leukomalacia (PVL) is the most common cause of cerebral palsy (CP) in preterm infant. Activated leukocytes are the main source of inflammatory cytokines that give rise to white matter damage and CP in preterm infant. Here, we tested the hypothesis that inflammation profiles as pathogenic mediators for the occurrence of PVL in the neonatal period may persist in preterm children with CP at school age.

2009-09-30 | GSE17390 | GEO

Cerebral palsy serum proteomics

Project description:Cerebral palsy (CP), a prevalent non-progressive neurological disorder in children, lacks reliable biomarkers for early diagnosis, and its molecular mechanisms remain poorly understood. In this study, we conducted serum proteomic profiling of 346 CP patients and 190 healthy controls and developed a 10-protein multi-marker panel for application in diagnosis of CP.

| PXD068404 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data