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Illumina raw files - samples

ABSTRACT: Illumina HT 12 IDATS

OTHER RELATED OMICS DATASETS IN: PRJNA130809

PROVIDER: EGAD00010000160 | EGA |

REPOSITORIES: EGA

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ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

Holland Daniel G DG Burleigh Angela A Git Anna A Goldgraben Mae A MA Perez-Mancera Pedro A PA Chin Suet-Feung SF Hurtado Antonio A Bruna Alejandra A Ali H Raza HR Greenwood Wendy W Dunning Mark J MJ Samarajiwa Shamith S Menon Suraj S Rueda Oscar M OM Lynch Andy G AG McKinney Steven S Ellis Ian O IO Eaves Connie J CJ Carroll Jason S JS Curtis Christina C Aparicio Samuel S Caldas Carlos C

EMBO molecular medicine 20110218 3

The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification was shown to correlate with increased gene and protein expression and was associated with a distinct expression signature and poor clinical outcome. ZNF703 transformed NIH 3T3 fibroblasts, behaving as ...[more]

PMID: 21337521

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