Dataset Information
SNP6_dataset_control - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000504 | EGA |
REPOSITORIES: EGA
Publications
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.
The Journal of pathology 20130901 1
High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity within primary, untreated HGSCs to examine the natural state of tumour evolution prior to therapy. We performed exome sequencing, copy number analysis, targeted amplicon deep sequencing and gene expression profiling on 31 spatially and temporally separated HGSC tumour specimens (six patients), including ...[more]