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Matched_normal_Affymetrix - samples

ABSTRACT: Matched control samples using SNP 6.0 Array

PROVIDER: EGAD00010000508 | EGA |

REPOSITORIES: EGA

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Mutational context and diverse clonal development in early and late bladder cancer.

Nordentoft Iver I Lamy Philippe P Birkenkamp-Demtröder Karin K Shumansky Karey K Vang Søren S Hornshøj Henrik H Juul Malene M Villesen Palle P Hedegaard Jakob J Roth Andrew A Thorsen Kasper K Høyer Søren S Borre Michael M Reinert Thomas T Fristrup Niels N Dyrskjøt Lars L Shah Sohrab S Pedersen Jakob Skou JS Ørntoft Torben F TF

Cell reports 20140515 5

Bladder cancer (or urothelial cell carcinoma [UCC]) is characterized by field disease (malignant alterations in surrounding mucosa) and frequent recurrences. Whole-genome, exome, and transcriptome sequencing of 38 tumors, including four metachronous tumor pairs and 20 superficial tumors, identified an APOBEC mutational signature in one-third. This was biased toward the sense strand, correlated with mean expression level, and clustered near breakpoints. A>G mutations were up to eight times more f ...[more]

PMID: 24835989

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