Dataset Information
CA_SNP_6.0 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000546 | EGA |
REPOSITORIES: EGA
Publications
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.
Nature communications 20140327
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modifiers and subunits of the SWI/SNF complex are mutated in 40 and 22.2% of the cases, respectively, with M ...[more]