Genomics

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WTCCC2 VL Brazil - samples

ABSTRACT: WTCCC2 Visceral Leishmaniasis samples from Brazil using Illumina 670k

PROVIDER: EGAD00010000636 | EGA |

REPOSITORIES: EGA

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Publications

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.

Fakiola Michaela M   Strange Amy A   Cordell Heather J HJ   Miller E Nancy EN   Pirinen Matti M   Su Zhan Z   Mishra Anshuman A   Mehrotra Sanjana S   Monteiro Gloria R GR   Band Gavin G   Bellenguez Céline C   Dronov Serge S   Edkins Sarah S   Freeman Colin C   Giannoulatou Eleni E   Gray Emma E   Hunt Sarah E SE   Lacerda Henio G HG   Langford Cordelia C   Pearson Richard R   Pontes Núbia N NN   Rai Madhukar M   Singh Shri P SP   Smith Linda L   Sousa Olivia O   Vukcevic Damjan D   Bramon Elvira E   Brown Matthew A MA   Casas Juan P JP   Corvin Aiden A   Duncanson Audrey A   Jankowski Janusz J   Markus Hugh S HS   Mathew Christopher G CG   Palmer Colin N A CN   Plomin Robert R   Rautanen Anna A   Sawcer Stephen J SJ   Trembath Richard C RC   Viswanathan Ananth C AC   Wood Nicholas W NW   Wilson Mary E ME   Deloukas Panos P   Peltonen Leena L   Christiansen Frank F   Witt Campbell C   Jeronimo Selma M B SM   Sundar Shyam S   Spencer Chris C A CC   Blackwell Jenefer M JM   Donnelly Peter P  

Nature genetics 20130106 2

To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, and combined analysis across the three cohorts for rs92  ...[more]

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