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GBM_Triplet_GWSNP6_Control - samples

ABSTRACT: Control samples using SNP 6.0 Arrays

PROVIDER: EGAD00010000654 | EGA |

REPOSITORIES: EGA

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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.

Kim Hoon H Zheng Siyuan S Amini Seyed S SS Virk Selene M SM Mikkelsen Tom T Brat Daniel J DJ Grimsby Jonna J Sougnez Carrie C Muller Florian F Hu Jian J Sloan Andrew E AE Cohen Mark L ML Van Meir Erwin G EG Scarpace Lisa L Laird Peter W PW Weinstein John N JN Lander Eric S ES Gabriel Stacey S Getz Gad G Meyerson Matthew M Chin Lynda L Barnholtz-Sloan Jill S JS Verhaak Roel G W RG

Genome research 20150203 3

Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼ 7 mo after diagnosis. Understanding the molecular architecture of this residual population is critical for the development of successful therapies. We used whole-genome sequencing and whole-exome sequencing of multiple sectors from primary and paired recurrent GBM tumors to rec ...[more]

PMID: 25650244

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