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PCGP ETP ALL SNP6 - samples

ABSTRACT: PCGP ETP ALL SNP6

PROVIDER: EGAD00010000696 | EGA |

REPOSITORIES: EGA

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Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

Maude Shannon L SL Dolai Sibasish S Delgado-Martin Cristina C Vincent Tiffaney T Robbins Alissa A Selvanathan Arthavan A Ryan Theresa T Hall Junior J Wood Andrew C AC Tasian Sarah K SK Hunger Stephen P SP Loh Mignon L ML Mullighan Charles G CG Wood Brent L BL Hermiston Michelle L ML Grupp Stephan A SA Lock Richard B RB Teachey David T DT

Blood 20150202 11

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile, as well as a high rate of induction failure. Frequent mutations in cytokine receptor and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways led us to hypothesize that ETP-ALL is dependent on JAK/STAT signaling. Here we demonstrate aberrant activation of the JAK/STAT pathway in ETP-ALL bla ...[more]

PMID: 25645356

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