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Pol2Chip

ABSTRACT: Pol2

PROVIDER: EGAD00010000860 | EGA |

REPOSITORIES: EGA

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Publications

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

Tufegdzic Vidakovic Ana A Rueda Oscar M OM Vervoort Stephin J SJ Sati Batra Ankita A Goldgraben Mae Akilina MA Uribe-Lewis Santiago S Greenwood Wendy W Coffer Paul J PJ Bruna Alejandra A Caldas Carlos C

Cell reports 20151210 11

The transforming growth factor beta (TGF-β) signaling pathway exerts opposing effects on cancer cells, acting as either a tumor promoter or a tumor suppressor. Here, we show that these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGF-β signaling, and the distinct epigenomes of breast-tumor-initiating cells (BTICs). These effects of TGF-β are associated with distinct gene expression programs, but genomic SMAD3 binding patterns are highly similar in the BTIC ...[more]

PMID: 26686634

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