Dataset Information

Pe_meta_20170131

ABSTRACT: Inverse variance weighted fixed effect meta-analysis of three European GWAS studies of the offspring of Pre-eclampsia affected births (2658 Cases and 308267 Controls).

PROVIDER: EGAD00010001211 | EGA |

REPOSITORIES: EGA

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Publications

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

McGinnis Ralph R Steinthorsdottir Valgerdur V Williams Nicholas O NO Thorleifsson Gudmar G Shooter Scott S Hjartardottir Sigrun S Bumpstead Suzannah S Stefansdottir Lilja L Hildyard Lucy L Sigurdsson Jon K JK Kemp John P JP Silva Gabriela B GB Thomsen Liv Cecilie V LCV Jääskeläinen Tiina T Kajantie Eero E Chappell Sally S Kalsheker Noor N Moffett Ashley A Hiby Susan S Lee Wai Kwong WK Padmanabhan Sandosh S Simpson Nigel A B NAB Dolby Vivien A VA Staines-Urias Eleonora E Engel Stephanie M SM Haugan Anita A Trogstad Lill L Svyatova Gulnara G Zakhidova Nodira N Najmutdinova Dilbar D Dominiczak Anna F AF Gjessing Håkon K HK Casas Juan P JP Dudbridge Frank F Walker James J JJ Pipkin Fiona Broughton FB Thorsteinsdottir Unnur U Geirsson Reynir T RT Lawlor Debbie A DA Iversen Ann-Charlotte AC Magnus Per P Laivuori Hannele H Stefansson Kari K Morgan Linda L

Nature genetics 20170619 8

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility loc ...[more]

PMID: 28628106

Dataset Information

Pe_meta_20170131

Publications

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

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