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Codelink_HWG_CLD_B

ABSTRACT: Codelink Human Whole Genome from Blood taken at 72 hours after birht

PROVIDER: EGAD00010001424 | EGA |

REPOSITORIES: EGA

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Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.

Oak Prajakta P Pritzke Tina T Thiel Isabella I Koschlig Markus M Mous Daphne S DS Windhorst Anita A Jain Noopur N Eickelberg Oliver O Foerster Kai K Schulze Andreas A Goepel Wolfgang W Reicherzer Tobias T Ehrhardt Harald H Rottier Robbert J RJ Ahnert Peter P Gortner Ludwig L Desai Tushar J TJ Hilgendorff Anne A

EMBO molecular medicine 20171101 11

Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O2). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O2 In the context of MV-O2, attenuated PDGF ...[more]

PMID: 28923828

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