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1958 British Birth Cohort

ABSTRACT: The National Child Development Study (NCDS) - also known as the 1958 British Birth Cohort (1958BC) - is a continuing, multi-disciplinary longitudinal study which takes as its subjects all the people born in one week in March 1958 in England, Scotland and Wales. The resource is used widely for research in genetic and genomic epidemiology - in particular as a platform for genetic association studies. Data are released under various Data Access Agreements. (1) Data users requesting genotype data only should apply to the Wellcome Trust Case Control consortium Data Access Committee (EGAC00000000001). (2) Those requesting phenotype data only should apply to the (ESRC) UK Data Archive (for more information please email to help@esds.ac.uk). (3) Those requesting linked genotype and phenotype data should apply to the Access Committee for the CLS Cohorts (for more information email to cohort1958@le.ac.uk).

PROVIDER: EGAO00000000016 | EGA |

REPOSITORIES: EGA

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Publications

A large-scale, consortium-based genomewide association study of asthma.

Moffatt Miriam F MF   Gut Ivo G IG   Demenais Florence F   Strachan David P DP   Bouzigon Emmanuelle E   Heath Simon S   von Mutius Erika E   Farrall Martin M   Lathrop Mark M   Cookson William O C M WOCM  

The New England journal of medicine 20100901 13

<h4>Background</h4>Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.<h4>Methods</h4>We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected perso  ...[more]

PMID: 20860503

Publication: 1/5

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