Dataset Information
University of Cambridge & Cancer Research UK Cambridge Research Institute
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA130809
PROVIDER: EGAO00000000061 | EGA |
REPOSITORIES: EGA
Publications
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
EMBO molecular medicine 20110218 3
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification was shown to correlate with increased gene and protein expression and was associated with a distinct expression signature and poor clinical outcome. ZNF703 transformed NIH 3T3 fibroblasts, behaving as ...[more]
