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MRC Biostatistics Unit, Cambridge

ABSTRACT: Organisation EGAO00000000127

PROVIDER: EGAO00000000127 | EGA |

REPOSITORIES: EGA

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Modelling local gene networks increases power to detect trans-acting genetic effects on gene expression.

Rakitsch Barbara B   Stegle Oliver O  

Genome biology 20160224

Expression quantitative trait loci (eQTL) mapping is a widely used tool to study the genetics of gene expression. Confounding factors and the burden of multiple testing limit the ability to map distal trans eQTLs, which is important to understand downstream genetic effects on genes and pathways. We propose a two-stage linear mixed model that first learns local directed gene-regulatory networks to then condition on the expression levels of selected genes. We show that this covariate selection app  ...[more]

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