Other

Dataset Information

1K

University of Cambridge & Cancer Research UK Cambridge Institute


ABSTRACT: Organisation EGAO00000000147

PROVIDER: EGAO00000000147 | EGA |

REPOSITORIES: EGA

altmetric image

Publications


Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator. Although EMSY has been linked to transcriptional silencing, its mechanism of action is unknown. Here, we report that EMSY acts as an oncogene, causing the transformation of cells in vitro and potentiating tumor formation and metastatic features in vivo. We identify an inverse correlation between EMSY amplification and miR-31 expression, an antimetastatic microRNA, in the METABRIC cohort of human  ...[more]

Similar Datasets

| EGAO00000000061 | EGA
| EGAO00000000619 | EGA
| EGAO00000000060 | EGA
| EGAO00000000823 | EGA
| EGAO00000000478 | EGA
| EGAO00000000646 | EGA
| S-BSST1126 | biostudies-other
| EGAO00000000349 | EGA
| EGAO00000000038 | EGA