Dataset Information
UT-PED
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000200 | EGA |
REPOSITORIES: EGA
Publications
Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.
Nature communications 20150703
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and clinical behaviours. A1 and A2 subtypes, especially A1, largely correspond to alveolar ...[more]
