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Dataset Information

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CRUK-LRI

ABSTRACT: Organisation EGAO00000000203

PROVIDER: EGAO00000000203 | EGA |

REPOSITORIES: EGA

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Publications

Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p  ...[more]

PMID: 24487277

Publication: 1/2

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