Other

Dataset Information

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The University of Queensland, Department of Surgery, Princess Alexandra Hospital

ABSTRACT: Organisation EGAO00000000250

PROVIDER: EGAO00000000250 | EGA |

REPOSITORIES: EGA

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Publications

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

Nones Katia K   Waddell Nicola N   Wayte Nicci N   Patch Ann-Marie AM   Bailey Peter P   Newell Felicity F   Holmes Oliver O   Fink J Lynn JL   Quinn Michael C J MCJ   Tang Yue Hang YH   Lampe Guy G   Quek Kelly K   Loffler Kelly A KA   Manning Suzanne S   Idrisoglu Senel S   Miller David D   Xu Qinying Q   Waddell Nick N   Wilson Peter J PJ   Bruxner Timothy J C TJC   Christ Angelika N AN   Harliwong Ivon I   Nourse Craig C   Nourbakhsh Ehsan E   Anderson Matthew M   Kazakoff Stephen S   Leonard Conrad C   Wood Scott S   Simpson Peter T PT   Reid Lynne E LE   Krause Lutz L   Hussey Damian J DJ   Watson David I DI   Lord Reginald V RV   Nancarrow Derek D   Phillips Wayne A WA   Gotley David D   Smithers B Mark BM   Whiteman David C DC   Hayward Nicholas K NK   Campbell Peter J PJ   Pearson John V JV   Grimmond Sean M SM   Barbour Andrew P AP  

Nature communications 20141029

Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC  ...[more]

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