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Dataset Information

1K

Hospital St Joan de Déu, Barcelona


ABSTRACT: Organisation EGAO00000000251

PROVIDER: EGAO00000000251 | EGA |

REPOSITORIES: EGA

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Publications


Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations in  ...[more]

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