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Institut Biologia Evolutiva

ABSTRACT: Organisation EGAO00000000324

PROVIDER: EGAO00000000324 | EGA |

REPOSITORIES: EGA

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Publications

Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.

Engelken Johannes J   Espadas Guadalupe G   Mancuso Francesco M FM   Bonet Nuria N   Scherr Anna-Lena AL   Jímenez-Álvarez Victoria V   Codina-Solà Marta M   Medina-Stacey Daniel D   Spataro Nino N   Stoneking Mark M   Calafell Francesc F   Sabidó Eduard E   Bosch Elena E  

Molecular biology and evolution 20151117 3

Essential trace elements possess vital functions at molecular, cellular, and physiological levels in health and disease, and they are tightly regulated in the human body. In order to assess variability and potential adaptive evolution of trace element homeostasis, we quantified 18 trace elements in 150 liver samples, together with the expression levels of 90 genes and abundances of 40 proteins involved in their homeostasis. Additionally, we genotyped 169 single nucleotide polymorphism (SNPs) in  ...[more]

PMID: 26582562

Publication: 1/2

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