Dataset Information
King's College London, St Thomas’ Campus, Lambeth Palace Road,London, UK
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000373 | EGA |
REPOSITORIES: EGA
Publications
Genetic interactions affecting human gene expression identified by variance association mapping.
eLife 20140425
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci. Interactions give rise to genotype dependent variance, and therefore the identification of variance quantitative trait loci can be an intermediate step to discover both epistasis and gene by environment effects (GxE). Using RNA-sequence data from lymphoblastoid cell lines (LCLs) from the TwinsUK cohor ...[more]
