Other,Multiomics

Dataset Information

1K

ICR-PTGT

ABSTRACT: Organisation EGAO00000000377

PROVIDER: EGAO00000000377 | EGA |

REPOSITORIES: EGA

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Publications

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.

Melin Beatrice S BS   Barnholtz-Sloan Jill S JS   Wrensch Margaret R MR   Johansen Christoffer C   Il'yasova Dora D   Kinnersley Ben B   Ostrom Quinn T QT   Labreche Karim K   Chen Yanwen Y   Armstrong Georgina G   Liu Yanhong Y   Eckel-Passow Jeanette E JE   Decker Paul A PA   Labussière Marianne M   Idbaih Ahmed A   Hoang-Xuan Khe K   Di Stefano Anna-Luisa AL   Mokhtari Karima K   Delattre Jean-Yves JY   Broderick Peter P   Galan Pilar P   Gousias Konstantinos K   Schramm Johannes J   Schoemaker Minouk J MJ   Fleming Sarah J SJ   Herms Stefan S   Heilmann Stefanie S   Nöthen Markus M MM   Wichmann Heinz-Erich HE   Schreiber Stefan S   Swerdlow Anthony A   Lathrop Mark M   Simon Matthias M   Sanson Marc M   Andersson Ulrika U   Rajaraman Preetha P   Chanock Stephen S   Linet Martha M   Wang Zhaoming Z   Yeager Meredith M   Wiencke John K JK   Hansen Helen H   McCoy Lucie L   Rice Terri T   Kosel Matthew L ML   Sicotte Hugues H   Amos Christopher I CI   Bernstein Jonine L JL   Davis Faith F   Lachance Dan D   Lau Ching C   Merrell Ryan T RT   Shildkraut Joellen J   Ali-Osman Francis F   Sadetzki Siegal S   Scheurer Michael M   Shete Sanjay S   Lai Rose K RK   Claus Elizabeth B EB   Olson Sara H SH   Jenkins Robert B RB   Houlston Richard S RS   Bondy Melissa L ML  

Nature genetics 20170327 5

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10<sup>-9</sup>, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10<sup>-10</sup>, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 ×  ...[more]

PMID: 28346443

Publication: 1/4

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