Dataset Information
ICR-GM
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000407 | EGA |
REPOSITORIES: EGA
Publications
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma.
Nature communications 20150423
We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutational signature is seen in 3.8% of cases and is linked to the translocation-mediated deregulation of MAF and MAFB, a known poor prognostic factor. Patients with this signature have ...[more]
