Other,Multiomics

Dataset Information

1K

Assistance publique – Hôpitaux de Paris (AP-HP)

ABSTRACT: Organisation EGAO00000000443

PROVIDER: EGAO00000000443 | EGA |

REPOSITORIES: EGA

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Publications

Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurrent mutations in TCF12 and in an additional series of 83 AO. Overall, 7.5% of AO are mutated for TCF12, w  ...[more]

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