Dataset Information
Service de neurologie Mazarin CHU Paris-GH La Pitié-Salpêtrière
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000444 | EGA |
REPOSITORIES: EGA
Publications
TCF12 is mutated in anaplastic oligodendroglioma.
Nature communications 20150612
Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurrent mutations in TCF12 and in an additional series of 83 AO. Overall, 7.5% of AO are mutated for TCF12, w ...[more]
