Other

Dataset Information

1K

Charité Universitätsmedizin Berlin

ABSTRACT: Organisation EGAO00000000581

PROVIDER: EGAO00000000581 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.

Schulze Heuling Eva E   Knab Felix F   Radke Josefine J   Eskilsson Eskil E   Martinez-Ledesma Emmanuel E   Koch Arend A   Czabanka Marcus M   Dieterich Christoph C   Verhaak Roel G RG   Harms Christoph C   Euskirchen Philipp P  

Molecular cancer research : MCR 20170201 5

Promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is a critical biomarker in glioblastoma (GBM), as treatment decisions and clinical trial inclusion rely on its accurate assessment. However, interpretation of results is complicated by poor interassay reproducibility as well as a weak correlation between methylation status and expression levels of MGMT. This study systematically investigates the influence of tumor purity on tissue subjected to MGM  ...[more]

Similar Datasets

Other Charité, Universitätsmedizin Berlin
| EGAO00000000879 | EGA
Other Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany
| EGAO00000000886 | EGA
Other Charité - Universitätsmedizin Berlin, Institut für Pathologie
| EGAO00000000632 | EGA
Other Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Institut für Pathologie
| EGAO00000000601 | EGA
Other Université Laval
| EGAO00000000805 | EGA
Other Université de Montréal
| EGAO00000001199 | EGA
Other Universitätsmedizin Mannheim
| EGAO00000001380 | EGA
Other Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse UMR 5288 CNRS, Université Toul
| EGAO00000000764 | EGA
Other Service de Génétique, HEGP
| EGAO00000000308 | EGA
Other Universitätsklinikum Heidelberg
| EGAO00000000741 | EGA