Dataset Information
Gothenburg University
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000649 | EGA |
REPOSITORIES: EGA
Publications
A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma.
PloS one 20170427 4
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g. BRAFV600E). These features may serve as diagnostic and prognostic markers, and also facilitate development of targeted therapy. The aims of this study were to characterize the genetic alterations underlying the development ...[more]
