Dataset Information

Harvard University

ABSTRACT: Organisation EGAO00000000825

PROVIDER: EGAO00000000825 | EGA |

REPOSITORIES: EGA

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Publications

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.

Merkle Florian T FT Ghosh Sulagna S Kamitaki Nolan N Mitchell Jana J Avior Yishai Y Mello Curtis C Kashin Seva S Mekhoubad Shila S Ilic Dusko D Charlton Maura M Saphier Genevieve G Handsaker Robert E RE Genovese Giulio G Bar Shiran S Benvenisty Nissim N McCarroll Steven A SA Eggan Kevin K

Nature 20170426 7653

Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells with a growth advantage in culture. The nature, extent and functional effects of other acquired genome sequence mutations in cultured hPS cells are not known. Here we sequence the protein-coding genes (exomes) of 140 independent human embryonic stem ...[more]

PMID: 28445466

Dataset Information

Harvard University

Publications

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.

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