Genomics

Dataset Information

6

WTCCC case-control study for Inflammatory Bowel Disease, T1D and RA - combined cases


ABSTRACT: WTCCC genome-wide case-control association study using three disease collections together with the 1958 British Birth Cohort and the UK National Blood Service collections as controls.

ORGANISM(S): Homo sapiens  

PROVIDER: EGAS00000000008 | EGA |

REPOSITORIES: EGA

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Publications

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Nature 20070601 7145


There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5  ...[more]

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