Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

ABSTRACT: We have used next generation sequencing to sequence genomes (>43-fold coverage) and transcriptomes of an oestrogen-receptor-alpha-positive metastatic lobular breast cancer at depth. We found 32 somatic non-synonymous coding mutations present in the metastasis, and measured the frequency of these somatic mutations in DNA from the primary tumour of the same patient.

PROVIDER: EGAS00000000054 | EGA |

REPOSITORIES: EGA