Genomics

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Complex Landscapes of Somatic Rearrangements in Human Breast Cancer Genomes

ABSTRACT: We have used massively parallel paired end sequencing strategies to reconstruct the genomic landscape of 24 breast cancer genomes, through the identification and characterization of 2166 somatically acquired genomic rearrangements. These studies have revealed considerable complexity in the patterns of structural variation, identified novel fusion genes and unveiled new insights into the complex structure of amplicons.

PROVIDER: EGAS00000000062 | EGA |

REPOSITORIES: EGA

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Publications

Complex landscapes of somatic rearrangement in human breast cancer genomes.

Stephens Philip J PJ   McBride David J DJ   Lin Meng-Lay ML   Varela Ignacio I   Pleasance Erin D ED   Simpson Jared T JT   Stebbings Lucy A LA   Leroy Catherine C   Edkins Sarah S   Mudie Laura J LJ   Greenman Chris D CD   Jia Mingming M   Latimer Calli C   Teague Jon W JW   Lau King Wai KW   Burton John J   Quail Michael A MA   Swerdlow Harold H   Churcher Carol C   Natrajan Rachael R   Sieuwerts Anieta M AM   Martens John W M JW   Silver Daniel P DP   Langerød Anita A   Russnes Hege E G HE   Foekens John A JA   Reis-Filho Jorge S JS   van 't Veer Laura L   Richardson Andrea L AL   Børresen-Dale Anne-Lise AL   Campbell Peter J PJ   Futreal P Andrew PA   Stratton Michael R MR  

Nature 20091201 7276

Multiple somatic rearrangements are often found in cancer genomes; however, the underlying processes of rearrangement and their contribution to cancer development are poorly characterized. Here we use a paired-end sequencing strategy to identify somatic rearrangements in breast cancer genomes. There are more rearrangements in some breast cancers than previously appreciated. Rearrangements are more frequent over gene footprints and most are intrachromosomal. Multiple rearrangement architectures a  ...[more]

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