Complex Landscapes of Somatic Rearrangements in Human Breast Cancer Genomes

ABSTRACT: We have used massively parallel paired end sequencing strategies to reconstruct the genomic landscape of 24 breast cancer genomes, through the identification and characterization of 2166 somatically acquired genomic rearrangements. These studies have revealed considerable complexity in the patterns of structural variation, identified novel fusion genes and unveiled new insights into the complex structure of amplicons.

PROVIDER: EGAS00000000062 | EGA |

REPOSITORIES: EGA