Genomics

Dataset Information

8

Genome Landscape of Primary Pancreatic Ductal Adenocarcinoma

ABSTRACT: The purpose of the Australian ICGC Pancreatic Cancer Genome Sequencing Initiative study is to identify the common driving mutations underlying the initiation and development of Pancreatic Adenocarcinoma in a large cohort of pancreatic cancer patients (n=350). Matched genome sequences will be generated from normal tissue (duodenum) and resected primary tumour tissue in each patient using exome and whole genome sequencing. The complete repertoire of somatic mutations will be determined (substitutions, indels, copy number changes and structural changes). Where possible, matched transcriptome sequencing will also be carried out to determine locus activity, which mutations are actively expressed and which rearrangements give rise to gene-fusion transcripts.

PROVIDER: EGAS00001000154 | EGA |

REPOSITORIES: EGA

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Publications

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Biankin Andrew V AV   Waddell Nicola N   Kassahn Karin S KS   Gingras Marie-Claude MC   Muthuswamy Lakshmi B LB   Johns Amber L AL   Miller David K DK   Wilson Peter J PJ   Patch Ann-Marie AM   Wu Jianmin J   Chang David K DK   Cowley Mark J MJ   Gardiner Brooke B BB   Song Sarah S   Harliwong Ivon I   Idrisoglu Senel S   Nourse Craig C   Nourbakhsh Ehsan E   Manning Suzanne S   Wani Shivangi S   Gongora Milena M   Pajic Marina M   Scarlett Christopher J CJ   Gill Anthony J AJ   Pinho Andreia V AV   Rooman Ilse I   Anderson Matthew M   Holmes Oliver O   Leonard Conrad C   Taylor Darrin D   Wood Scott S   Xu Qinying Q   Nones Katia K   Fink J Lynn JL   Christ Angelika A   Bruxner Tim T   Cloonan Nicole N   Kolle Gabriel G   Newell Felicity F   Pinese Mark M   Mead R Scott RS   Humphris Jeremy L JL   Kaplan Warren W   Jones Marc D MD   Colvin Emily K EK   Nagrial Adnan M AM   Humphrey Emily S ES   Chou Angela A   Chin Venessa T VT   Chantrill Lorraine A LA   Mawson Amanda A   Samra Jaswinder S JS   Kench James G JG   Lovell Jessica A JA   Daly Roger J RJ   Merrett Neil D ND   Toon Christopher C   Epari Krishna K   Nguyen Nam Q NQ   Barbour Andrew A   Zeps Nikolajs N   Kakkar Nipun N   Zhao Fengmei F   Wu Yuan Qing YQ   Wang Min M   Muzny Donna M DM   Fisher William E WE   Brunicardi F Charles FC   Hodges Sally E SE   Reid Jeffrey G JG   Drummond Jennifer J   Chang Kyle K   Han Yi Y   Lewis Lora R LR   Dinh Huyen H   Buhay Christian J CJ   Beck Timothy T   Timms Lee L   Sam Michelle M   Begley Kimberly K   Brown Andrew A   Pai Deepa D   Panchal Ami A   Buchner Nicholas N   De Borja Richard R   Denroche Robert E RE   Yung Christina K CK   Serra Stefano S   Onetto Nicole N   Mukhopadhyay Debabrata D   Tsao Ming-Sound MS   Shaw Patricia A PA   Petersen Gloria M GM   Gallinger Steven S   Hruban Ralph H RH   Maitra Anirban A   Iacobuzio-Donahue Christine A CA   Schulick Richard D RD   Wolfgang Christopher L CL   Morgan Richard A RA   Lawlor Rita T RT   Capelli Paola P   Corbo Vincenzo V   Scardoni Maria M   Tortora Giampaolo G   Tempero Margaret A MA   Mann Karen M KM   Jenkins Nancy A NA   Perez-Mancera Pedro A PA   Adams David J DJ   Largaespada David A DA   Wessels Lodewyk F A LF   Rust Alistair G AG   Stein Lincoln D LD   Tuveson David A DA   Copeland Neal G NG   Musgrove Elizabeth A EA   Scarpa Aldo A   Eshleman James R JR   Hudson Thomas J TJ   Sutherland Robert L RL   Wheeler David A DA   Pearson John V JV   McPherson John D JD   Gibbs Richard A RA   Grimmond Sean M SM  

Nature 20121024 7424

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutation  ...[more]

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