Genome Landscape of Primary Pancreatic Ductal Adenocarcinoma

ABSTRACT: The purpose of the Australian ICGC Pancreatic Cancer Genome Sequencing Initiative study is to identify the common driving mutations underlying the initiation and development of Pancreatic Adenocarcinoma in a large cohort of pancreatic cancer patients (n=350). Matched genome sequences will be generated from normal tissue (duodenum) and resected primary tumour tissue in each patient using exome and whole genome sequencing. The complete repertoire of somatic mutations will be determined (substitutions, indels, copy number changes and structural changes). Where possible, matched transcriptome sequencing will also be carried out to determine locus activity, which mutations are actively expressed and which rearrangements give rise to gene-fusion transcripts.

PROVIDER: EGAS00001000154 | EGA |

REPOSITORIES: EGA