Dataset Information

Pancreatic Cancer Sequencing Initiative

ABSTRACT: Pancreatic Cancer Sequencing Initiative for the International Cancer Genome Consortium at the Ontario Institute for Cancer Research.

PROVIDER: EGAS00001000343 | EGA |

REPOSITORIES: EGA

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Publications

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Biankin Andrew V AV Waddell Nicola N Kassahn Karin S KS Gingras Marie-Claude MC Muthuswamy Lakshmi B LB Johns Amber L AL Miller David K DK Wilson Peter J PJ Patch Ann-Marie AM Wu Jianmin J Chang David K DK Cowley Mark J MJ Gardiner Brooke B BB Song Sarah S Harliwong Ivon I Idrisoglu Senel S Nourse Craig C Nourbakhsh Ehsan E Manning Suzanne S Wani Shivangi S Gongora Milena M Pajic Marina M Scarlett Christopher J CJ Gill Anthony J AJ Pinho Andreia V AV Rooman Ilse I Anderson Matthew M Holmes Oliver O Leonard Conrad C Taylor Darrin D Wood Scott S Xu Qinying Q Nones Katia K Fink J Lynn JL Christ Angelika A Bruxner Tim T Cloonan Nicole N Kolle Gabriel G Newell Felicity F Pinese Mark M Mead R Scott RS Humphris Jeremy L JL Kaplan Warren W Jones Marc D MD Colvin Emily K EK Nagrial Adnan M AM Humphrey Emily S ES Chou Angela A Chin Venessa T VT Chantrill Lorraine A LA Mawson Amanda A Samra Jaswinder S JS Kench James G JG Lovell Jessica A JA Daly Roger J RJ Merrett Neil D ND Toon Christopher C Epari Krishna K Nguyen Nam Q NQ Barbour Andrew A Zeps Nikolajs N Kakkar Nipun N Zhao Fengmei F Wu Yuan Qing YQ Wang Min M Muzny Donna M DM Fisher William E WE Brunicardi F Charles FC Hodges Sally E SE Reid Jeffrey G JG Drummond Jennifer J Chang Kyle K Han Yi Y Lewis Lora R LR Dinh Huyen H Buhay Christian J CJ Beck Timothy T Timms Lee L Sam Michelle M Begley Kimberly K Brown Andrew A Pai Deepa D Panchal Ami A Buchner Nicholas N De Borja Richard R Denroche Robert E RE Yung Christina K CK Serra Stefano S Onetto Nicole N Mukhopadhyay Debabrata D Tsao Ming-Sound MS Shaw Patricia A PA Petersen Gloria M GM Gallinger Steven S Hruban Ralph H RH Maitra Anirban A Iacobuzio-Donahue Christine A CA Schulick Richard D RD Wolfgang Christopher L CL Morgan Richard A RA Lawlor Rita T RT Capelli Paola P Corbo Vincenzo V Scardoni Maria M Tortora Giampaolo G Tempero Margaret A MA Mann Karen M KM Jenkins Nancy A NA Perez-Mancera Pedro A PA Adams David J DJ Largaespada David A DA Wessels Lodewyk F A LF Rust Alistair G AG Stein Lincoln D LD Tuveson David A DA Copeland Neal G NG Musgrove Elizabeth A EA Scarpa Aldo A Eshleman James R JR Hudson Thomas J TJ Sutherland Robert L RL Wheeler David A DA Pearson John V JV McPherson John D JD Gibbs Richard A RA Grimmond Sean M SM

Nature 20121024 7424

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutation ...[more]

PMID: 23103869

Dataset Information

Pancreatic Cancer Sequencing Initiative

Publications

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

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