The landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes

ABSTRACT: To define the frequency and pattern of somatic mutations in epigenetic regulators in pediatric cancer, we sequenced 633 genes, encoding the majority of proteins involved in patterning the epigenome, in 1000 pediatric tumors spanning 21 different cancer subtypes. This analysis establishes an epigenetic landscape of pediatric cancer, which expands the knowledge for potential therapeutic targets and for developing personalized therapy.

PROVIDER: EGAS00001000449 | EGA |

REPOSITORIES: EGA